Axio Observer for Life Science Research

Life sciences research calls for reproducible data from a whole range of samples in a variety of conditions. ZEISS Axio Observer is your stable inverse platform for demanding multimodal imaging of living and fixed specimens, giving you: 

  • Ensured flexibility for technologies ranging from widefield to gentle super-resolution imaging
  • Unique guidance through your experiments – from sample placement to selecting the perfect imaging modalities
  • Increased efficiency thanks to a high degree of automation, economic light sources, and highest spectral flexibility

Flexibility for Your Research

Life sciences research is a dynamic environment in which your imaging requirements are always changing. As your needs grow, Axio Observer stays with you step by step. It offers an abundance of interfaces for technologies ranging from widefield transmitted light to convenient 3D sectioning with Apotome 3, and sensitive superresolution imaging with Elyra 7 or LSM 980 and Airyscan 2. Choose the optimal incubation equipment and enjoy easy sample access for precise micromanipulation. A great variety of integrated options makes your Axio Observer both versatile now and entirely future proof.


  • EEnsured flexibility for all technologies
  • EGuidance for Your Workflows
  • EEfficiency for Your Experiments
  • EAI Sample Finder
  • EApotome 3
  • EDefinite Focus 3

Guidance for Your Workflows

You will be amazed how easy imaging becomes when the AI Sample Finder automatically detects the sample carrier, adjusts the focus, and finds your sample region. Even with low-contrast samples, you will quickly obtain an overview image to access relevant regions with just a click. Reduce the time to image from minutes to just seconds and start your experiment right away. Let Smart Setup and the Focus Strategy Wizard guide you through the experimental setup for easy and intuitive selection of the imaging modalities for your applications. Using ZEN Connect, acquired images can be easily combined with electron microscopy data and other modalities.

Efficiency for Your Experiments

Expect a remarkable increase in efficiency with the automation functions of Axio Observer. Use fast switchable LEDs or go for powerful and economic white-light sources in combination with the fast filter wheel for highest spectral flexibility and speed. Select the ideal camera from the dedicated ZEISS Axiocam portfolio or from third-party suppliers: You will always get the image quality and speed your applications require. With Definite Focus 3, focus drift during complicated experiments is a thing of the past. Whether keeping your sample in focus for long-term imaging or adapting your objective to your sample, it’s all automatic with this highly organized system.