Zaber Nucleus Fluorescence Microscopy Platforms
High-speed fluorescence microscopy platforms built for flexibility and high throughput automated imaging
The Zaber Nucleus series is available in two distinct fluorescence microscopy platforms: the MVR Inverted and the MSR Upright. The MVR Inverted platform is designed for imaging samples in well plates or dishes, with the objective approaching from below—ideal for live-cell or high-throughput imaging. The MSR Upright platform, on the other hand, positions the objective above the sample, making it well-suited for thicker specimens, slides, or materials applications. Both systems are fully motorized and modular, offering automated XY and Z motion, filter cube changes, and compatibility with major optical components. Together, these platforms provide researchers and integrators flexible options for building advanced, automated fluorescence imaging systems.
MVR Inverted Fluorescence Microscopy Platform
The Zaber Nucleus MVR Inverted Fluorescence Microscopy Platform is a fully motorized, modular microscope system engineered for high-throughput and automated fluorescence imaging. Designed with an inverted configuration, it allows objectives to approach samples from below—ideal for imaging live cells, well plates, and culture dishes. The platform integrates precision motorized XY and Z motion, automated filter cube and objective changes, and supports transmitted light options such as brightfield or phase contrast. Compatible with leading optical components from manufacturers like Zeiss, Nikon, and Olympus, it also interfaces seamlessly with open-source software like µManager and Zaber’s Motion Library API for custom automation workflows. Combining flexibility, precision, and open architecture, the MVR platform provides a powerful foundation for both research laboratories and OEM system developers seeking to build advanced fluorescence microscopy solutions.
SPECIFICATIONS:
-
Motorized XY stage with travel up to 305 × 305 mm — supports scanning multi-well plates or large area slides.
-
Motorized Z-focus (linear motor) stage offering high speed and precision (e.g., sub-70 ms settle time for 1 µm move) and very fine incremental movement.
-
A 6-position motorized filter cube turret accommodating standard Zeiss style “push & click” filter cubes for multi-channel fluorescence.
-
Modular optics support: compatible with Zeiss, Nikon, Olympus or Edmund Optics objectives; universal tube-lens mount allows switching optical systems.
-
Optional transmitted illumination module (brightfield / phase contrast) and support for external light engines or liquid light‐guide coupling.
-
Open control architecture: fully compatible with open-source microscopy software µManager and programmable via Zaber Motion Library API for automation/custom workflows.
For further information, it is recommended to reach out to a representative from Nuhsbaum. Our representatives are knowledgeable about the Zaber Nucleus MVR Inverted Fluorescence Microscopy Platform offerings and can provide expert guidance and support in selecting the right configuration to meet specific research needs.
MSR Upright Flourescence Microscopy Platform
The Zaber Nucleus MSR Upright Fluorescence Microscopy Platform is a fully-motorized upright microscope system designed for high-throughput automated imaging of slides, well plates, or larger specimens. It features motorized XY and Z-focus movement, automatic filter cube and objective changes, and supports industry-standard optics from brands such as Zeiss, Nikon and Olympus. With a linear-motor focus stage supporting 20 nm minimum incremental moves and sub-25 ms settle times for small focus shifts, it offers high precision and repeatability (< 0.2 µm). The platform is modular and configurable, enabling users to build or expand their system with customised illumination, stages and optics as required. It also includes open-software support via the Zaber Motion Library API and compatibility with µManager open‐source microscopy software for flexible automation and integration.
SPECIFICATIONS:
-
Focus stage model: X‑LDA025A‑AE53D12
-
Focus stage encoder resolution: 1 nm
-
Focus stage minimum incremental move: 20 nm
-
Focus stage repeatability: < 0.2 µm
Typical focus stage move & settle times for different moves at 165 g load:
-
< 25 ms for 200 nm move
-
< 35 ms for 500 nm move
-
< 45 ms for 1000 nm move
-
-
Filter cube change time: 350 ms
-
Field Number (FN): 20 mm (0.787″)
-
Supports motorized XY and Z‑focus movement, motorized filter cube and objective changes for fully automated whole‑slide or well‑plate imaging.
- Optical system compatibility: Supports major systems (Zeiss, Nikon, Olympus) for objectives and tube lenses.
- Modular design allowing flexible combinations of modules (illuminators, stages, accessories) tailored to application.
For further information, it is recommended to reach out to a representative from Nuhsbaum. Our representatives are knowledgeable about the Zaber Nucleus MSR Upright Fluorescence Microscopy Platform offerings and can provide expert guidance and support in selecting the right configuration to meet specific research needs.
